Assistant Professor of Medicine
Ph.D., Department of Molecular and Tumor Pathology, Chiba University School of Medicine, Japan
1. Qiang YW, Chen Y, Brown N, Ho B, Epstein J, Barlogie B, and Shaughnessy J Jr. Characterization of Wnt/b-catenin signaling in osteoclasts in multiple myeloma. British Journal of Hematology. 2010; 148:726-38.
2. Qiang YW, Hu B, Chen Y, Zhong Y, Shi B, Barlogie B, Shaughnessy J Jr. Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling. Blood, 2009;113: 4319-30.
3. Qiang, YW, Chen Y, Stephens O, Brown N, Chen B, Epstein J, Barlogie B, and Shaughnessy JD Jr. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood. 2008,1112(1): 196-207
4. Qiang YW, Barlogie B, Rudikoff S and Shaughnessy J Jr. Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone, 2008; 42(4): 669-80
5. Qiang YW, Shaughnessy J Jr. and Yaccoby S. Wnt3a Signaling Within Bone Inhibits Multiple Myeloma Bone Disease and Tumor Growth. Blood, 2008;112(2): 374-82
6. Qiang YW, Walsh K, Yao L, Kedei N, Blumberg P, Rubin J, Shaughnessy J Jr. and Rudikoff S. Wnts induce migration and invasion of myeloma cells via activation of RhoA and PKC pathways. Blood. 2005; 106(5): 1786-93
7. Qiang YW and Rudikoff S. Wnt signaling in B and T lymphocytes. Front Biosci. 2004; 9: 1000-10
8. Qiang YW, Yao L, Tosato G, Rudikoff S. Insulin-like Growth Factor I induces migration and invasion of human multiple myeloma cells. Blood. 2004; 103(1): 301-8
9. Qiang YW, Endo Y, Rubin J, Rudikoff S. Wnt Signaling in B cell Neoplasia. Oncogene. 2003; 22(10): 1536-45