Joshua Epstein, D.Sc.

 

Professor of Medicine; Director of Basic and Translational Research; Director, Donna D. and Donald M. Lambert Laboratory of Myeloma Genetics

MSc Bar-Ilan University, Israelepstein
DSc (biology) Technion, Israel
Research Fellow, pediatrics, Genetic Unit, Harvard University School of Medicine, Boston, Massachusetts
Assistant Professor, pediatrics, John Hopkins University School of Medicine, Baltimore, Maryland
Assistant Professor, Laboratory of Experimental Oncology, Indiana University School of Medicine, Indianapolis, Indiana
Cancer Research Scientist, Department of Medical Oncology, Roswell Park Memorial Institute, Buffalo, New York
Associate Cell Biologist, Department of Hematology, M.D. Anderson Cancer Center, Houston, Texas

Selected Publications:

Dong W, Zhang T, Epstein J, Cooney L, Wang H, Li Y, Jiang Y-B, Cogbill A, Tian Z R. Multifunctional Nanowire Bioscaffolds on Titanium. Chemistry Materials 19, 4454-4459, 2007.

Epstein J, Walker R. Myeloma and bone disease (“the dangerous tango”). Clinical Advances in Hematology and Oncology 4:300-306, 2006.

Yaccoby S, Wezeman MJ, Zangari M, Walker R, Cottler-Fox M, Gaddy D, Ling W, Saha S, Barlogie B, Tricot T, Epstein J: Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and myelomatous SCID-hu mice. Haematologica. 2006;91:192-199.

Yaccoby S, Wezeman MJ, Henderson A, Fox MH, Yi Q, Barlogie B, Epstein J: Cancer and the microenvironment: Myeloma – osteoclast interactions as a model. Cancer Research 64:2016-2023, 2004.

Epstein J, Yaccoby S: Interactions between the bone marrow stroma and myeloma. The Hematology Journal 4:310-314, 2003.

Bhattacharyya S, Epstein J, Suva LJ, Biomarkers that discriminate multiple myeloma patients with or without skeletal involvement detected using SELDI-TOF mass spectrometry and statistical and machine learning tools. Disese Markers 2006. In press.

The bone marrow stromal environment is a major factor in myeloma cell resistance to dexamethasone.
Experimental Hematology 26:597-603, 1998.