Jeffrey Sawyer, Ph.D.

 

Professor of Pathology, UAMSsawyer
Director of Cytogenetics

Ph.D. Florida Institute of Technology, Melbourne, Florida
Director, Cytogenetics Laboratory, Clinical and Diagnostic Foundation, Driscoll Foundation Children’s Hospital, Corpus Christi, Texas

Selected Publications:

Sawyer JR, Erming Tian E, Thomas E, Mark Koller M, Stangeby C, Sammartino G, Goosen L, Swanson C, Lichti Binz R, Barlogie B, Shaughnessy, Jr. J. Evidence for a Novel Mechanism for Gene Amplification in Multiple Myeloma:1q12 Pericentromeric Heterochromatin Mediates Breakage-Fusion-Bridge Cycles of a 1q12~23 Amplicon. British Journal of Haematology 147:484-494, 2009.

Sawyer JR, Tricot G, Lukacs JL, Lichti-Binz R, Tain E, Barlogie B, Shaughnessy J.  Genomic Instability in Multiple Myeloma: Evidence for Jumping Segmental Duplications of Chromosome 1q.  Genes Chromosomes and Cancer,  42:95-106, 2005.

Hanamura I, Stewart JP, Huang U, Zhan F, Santra M, Sawyer JR, Hollmig K, Zangarri M, Pineda-Roman M, van Rhee F, Cavall F, Burington B, Crowley J, Tricot G, Barlogie B, Shaughnessy Jr. JD.  Frequent gain of chromosome band 1q21 in plasma cell dyscrasias detected by fluorescence in situ hybridization: Incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem cell transplantations.  Blood108:1724-1732, 2006.

Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, Hollimig K, Pineda-Roman M, Tricot G, van Rhee F, Walker R, Zangari M, Crowley J, Barlogie B, Shaughnessy Jr. JD.  The molecular classification of multiple myeloma.  Blood, 108:2020-2028, 2006.

Shaughnessy, Jr, J, Zhan F, Burington B, Huang Y, Colla S, Hanamura I,  Stewart J, Kordsmeier B, Randolph C, Williams D, Xiao Y, Xu H, Epstein j, Anaissie E,  Krishna S, Cottler-Fox M, Hollmig K, Mohiuddin A, Pineda-Roman M, Tricot G,  van Rhee F, Sawyer J, Alsayed Y, Walker R, Zangari M, Crowley J, Barlogie B. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Blood , 109:2276-2284, 2007

Barlogie B, Tricot G, Haessler J, van Rhee R, Cottler-Fox M, Annaisse E, Waldron J, Pineda-Roman M, thertulien R, Zangari M, hollmig K, Mohiuddin A, Alsyaed Y, hoering A, Crowley J, Sawyer J.  Cytogenetically defined myelodysplasia after melphalan-based autotranplants for multiple myeloma linked to poor hematopoietic stem-cell mobilization: the Arkansas experience in more than 3000 patients treated since 1989. Blood. 111:94-100, 2008.