Assistant Professor of Medicine

Education

1983  
MD
Xian Jiaotong University School of Medicine
Xian, China

1992 
MS, Hematology/Oncology
Xian Jiaotong University School of Medicine

1999   
PhD, Tumor and Molecular Pathology
Chiba University School of Medicine
Chiba, Japan

Postgraduate Training

1987 
Residency, Internal Medicine
First Affiliated Hospital
Xian Jiaotong University School of Medicine
Xian, China

1990  
Fellowship, Hematology
First Affiliated Hospital
Xian Jiaotong University School of Medicine

2000  
Post-doctoral Fellowship, Tumor and Molecular Pathology
Chiba University School of Medicine
Chiba, Japan

2005     
Post-doctoral Fellowship, Cellular and Molecular Biology
National Cancer Institute
National Institutes of Health
Bethesda, Maryland

Current Research

Dr. Qiang’s laboratory focuses on the Wnt signaling pathway in the pathogenesis of myeloma and identification of molecular targets for myeloma cells that are resistant to chemotherapy. The laboratory has characterized that Wnt signaling is activated in myeloma cells in order to regulate migration and invasion of myeloma cells. Disruption of Wnt signaling by myeloma-derived Dkk1 is an important mechanism underlying myeloma-triggered bone disease. In the bone marrow, Dkk1 suppresses the Wnt pathway. This leads directly to diminished differentiation of mesenchymal stem cells into osteoblasts and indirectly promotes osteoclast activity via de-regulation of RANK/OPG by osteoblasts in the bone marrow. Discoveries in Dr. Qiang’s laboratory have also generated mechanistic insight into how proteasome inhibitors act against bone disease by promoting differentiation of mesenchymal stromal cells via Wnt-independent activation of the beta-catenin-TCF pathway.

Dr. Qiang’s team is working to identify molecular targets in the tumor microenvironment that harbors myeloma cells that are resistant to chemotherapy.  They are also investigating the role of the MAF family in the development and progression of myeloma.  They are elucidating the molecular mechanisms underlying the protection of MAF protein from degradation and are identifying molecular targets that are regulated by MAF in order to develop novel therapies. 

Publications

Contact Information

Email: YQiang@uams.edu