Assistant Professor of Medicine

Education

1984
 MSc, Zoology
Bundelkhand University
Jhansi, India

1992
 PhD, Zoology
Banaras Hindu University
Varanasi, India

Postgraduate Training

2006
Post-doctoral Fellowship, Neurobiology and Developmental Sciences
University of Arkansas for Medical Sciences
Little Rock, Arkansas

2009 
Post-doctoral Fellowship, Multiple Myeloma
University of Arkansas for Medical Sciences

Current Research

Dr. Garg’s research is focused on developing highly activated expanded natural killer (ENK) cell therapy for genomically-defined high-risk relapsed multiple myeloma (MM). His lab has shown that highly activated natural killer cells can be generated in large numbers from the peripheral blood mononuclear cells of healthy donors and MM patients by co-culturing with K562 transfectants. These cells exert anti-myeloma effects in vivo and protected against tumor-mediated bone destruction in a murine model of human myeloma. It is critically important to determine, in those patients who fail ENK cell therapy, the underlying mechanisms of ENK resistance and whether there is intrinsic resistance or emergence of a more resistant myeloma cell clone, or whether ENK cells are being actively suppressed due to factors produced by the myeloma tumor/tumor microenvironment. Dr. Garg’s team has generated some ENK-resistant myeloma cell lines in the lab and is currently studying the different mechanisms of resistance by using gene expression profiling, phenotyping, quantitative proteomics, whole exome sequencing and RNA-seq.  In addition, Dr. Garg is also studying how the ENK cell activity is modulated by myeloma derived- exosomes and soluble factors.

Publications

Contact Information

Email: GargTarunK@uams.edu