Professor of Pathology
Director of Cytogenetics

Education

1971
BA, Psychology
University of Minnesota

1985
PhD, Biological Sciences
Florida Institute of Technology

Certification

American Board of Medical Specialties

American Board of Medical Genetics, Clinical Cytogenetics

Current Research

Dr. Sawyer’s research is focused on the cytogenetic analysis of multiple myeloma. His laboratory has combined the use of G-banding, florescence in situ hybridization (FISH) and Spectral Karyotyping (SKY) to identify  the  complex aberrations found in myeloma karyotypes. His laboratory has described multiple mechanisms for the amplification of chromosome region 1q21 in multiple myeloma, including “jumping translocations of 1q12” and a “breakage-fusion-bridge cycles” mechanism for these copy number gains. The 1q12 region literally jumps to multiple chromosomes, carrying the 1q21 region, which results in collateral damage across the genome in receptor chromosomes.  Since 1q21 is a copy number aberration associated with high-risk disease in myeloma, the understanding and eventual disruption of these types of aberrations are important in future therapeutic interventions.

Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=Sawyer+JR+University+of+Arkansas+for+Medical+Sciences

Contact Information

Email: SawyerJeffreyR@uams.edu