Professor of Pathology
Director of Cytogenetics
University of Minnesota
PhD, Biological Sciences
Florida Institute of Technology
American Board of Medical Specialties
American Board of Medical Genetics, Clinical Cytogenetics
Dr. Sawyer’s research is focused on the cytogenetic analysis of multiple myeloma. His laboratory has combined the use of G-banding, florescence in situ hybridization (FISH) and Spectral Karyotyping (SKY) to identify the complex aberrations found in myeloma karyotypes. His laboratory has described multiple mechanisms for the amplification of chromosome region 1q21 in multiple myeloma, including “jumping translocations of 1q12” and a “breakage-fusion-bridge cycles” mechanism for these copy number gains. The 1q12 region literally jumps to multiple chromosomes, carrying the 1q21 region, which results in collateral damage across the genome in receptor chromosomes. Since 1q21 is a copy number aberration associated with high-risk disease in myeloma, the understanding and eventual disruption of these types of aberrations are important in future therapeutic interventions.